The question of what cream to apply for osteoarthritis of the knee is also a common question encountered in outpatient clinics. For some patients who are not suitable for medication or surgery, especially the elderly, combined with other underlying diseases, surgery is difficult for such patients and taking medication is risky. In this case, it is safer to use topical patches, such as Loxone patch, Babu cream, compound Nanxing pain relief cream, etc., which are commonly used in clinical practice. Among them, Le Song paste is highly recommended to everyone, it does not cause allergic skin reactions, very suitable for the elderly with skin problems and prone to allergies. The specific medication needs to be combined with the clinical, subject to the guidance of the doctor’s interview.