Chewing muscle pain can be caused by temporomandibular joint disorder syndrome, maxillofacial peripheral gap infection and other diseases, general treatment, drug treatment and surgical treatment are feasible. 1. Temporomandibular joint disorder syndrome: caused by masticatory hyperfunction or spasm of masticatory muscle, related to incorrect sitting posture which leads to pulling of masticatory muscle by neck muscles, lateral chewing and teeth grinding. It is necessary to correct living habits, alternate chewing bilaterally when eating, and sit in the correct posture to avoid neck muscles pulling the masticatory muscles, but also under the guidance of the doctor to wear a jaw cushion treatment. 2. Maxillofacial peripheral gap infection: Infections occurring in the maxillofacial gap can involve the muscles and other tissues, resulting in symptoms of masticatory muscle pain. It can be treated with anti-infective drugs such as metronidazole or ceftriaxone under doctor’s guidance. If the infection causes abscess, if necessary, the abscess incision and drainage treatment. Chewing muscle pain should be timely medical consultation, under the guidance of the doctor to actively carry out the appropriate treatment, will help to early relief of the discomfort symptoms.