At present, SLE is not curable, but most patients can achieve remission with systematic and standardized treatment. SLE is an autoimmune disease that is essentially caused by the body’s immune system attacking its own cells. Existing studies have confirmed that abnormal immune inflammation is the pathological feature of SLE, and that genetics, infection, and estrogen are related to the development of SLE, but the specific etiology and pathogenesis remain unclear. Therefore, the current treatment is still mainly through drugs to suppress the immune response in order to delay the progression of the disease, reduce complications and protect the function of important organs, and there is no curative drug yet. Therefore, once patients reduce or stop the drugs on their own, or if the treatment is not standardized or systematic, the disease will be repeated. The inability to cure is by no means equal to the inability to control the progress of the disease. With the improvement of medical level and the development of a large number of new drugs, under systematic and standardized treatment, the condition of most patients can be in long-term stability and remission, and the prognosis and survival rate of SLE patients have been significantly improved compared with those in the past, and patients can work and live like normal people. Therefore, although SLE cannot be completely cured, it can be controlled without flare-ups. Early diagnosis, systematic and standardized treatment are the keys for SLE patients to keep their disease stable, and it is also necessary to maintain a good and healthy state of mind and establish self-confidence in treatment.