Serum γ-glutamyl transferase is one of the liver function tests, high value generally means that the liver is damaged, which may be caused by physiological factors and pathological factors, the specific causes and treatment methods are as follows: a. Physiological causes in the recent period of excessive fatigue, staying up late, drinking alcohol, overeating, etc., may cause acute liver injury, resulting in high value of γ-glutamyl transferase. This kind of liver injury is usually reversible and can be restored by quitting smoking, alcohol, light diet, and proper exercise, and after a period of time, the value will generally gradually drop to normal level. If the value does not drop or even continues to rise, you need to seek medical attention to further check the liver function, if there are other pathological reasons, you need to treat the condition in accordance with the corresponding. Second, the pathological reasons 1, liver disease: viral hepatitis, alcoholic hepatitis, steatohepatitis, etc. can be seen γ-glutamyl transferase elevated, patients often have fever, nausea, fatigue, anorexia, abdominal discomfort and other symptoms, serious visible jaundice and hepatosplenomegaly, can be detected by hepatitis virus markers, judgment. Chronic viral hepatitis can be treated with drugs such as interferon and famciclovir, while acute viral hepatitis requires absolute bed rest and control of protein content in the diet. Patients with alcoholic hepatitis must abstain from alcohol and give nutritional support, and can be treated with appropriate medications under the guidance of a doctor, and if necessary, surgery is feasible. Patients with steatohepatitis need to lose weight, control their diet and exercise actively. Patients with more serious hepatitis need to take orlistat, fibrates and other drugs as prescribed by the doctor, and if necessary, surgery. In addition, in primary liver cancer, γ-glutamyl transferase can be several times higher than the normal value, and secondary liver cancer can also increase the value significantly, but there are usually no significant symptoms in the early stage, which can only be detected by liver function test, methemoglobin test and hepatobiliary ultrasound. Therefore, if the value of γ-glutamyl transferase continues to be high for a long time, it is better to go to hospital for other related examinations to avoid delaying the disease; 2.Biliary obstruction: bile duct stones, biliary ascariasis, bile duct stenosis, biliary tumors and other diseases can cause biliary obstruction, which can compress and damage liver cells and elevate γ-glutamyl transferase, which can be diagnosed by hepatobiliary ultrasound, and if necessary, surgical treatment, and at the same time, close observation of liver Functional changes; 3, drug damage: long-term use of phenobarbital, phenytoin sodium, antipyrine, oral contraceptives, etc., may also make γ-glutamyl transferase mildly elevated. This situation can be observed for a period of time, if the value is only slightly high and basically stable, no other treatment can be done and regular review can be done. If the value continues to rise, a professional physician should determine whether to stop the medication or add liver protection drugs.