Myocardial bridge combined with st-segment depression indicates that there may be myocardial ischemia caused by myocardial bridge, and should be treated with medication, and those with poor results can choose surgical treatment on the basis of medication. 1. Drug therapy: β-blockers can slow down the heart rate, increase the diastolic coronary filling time, reduce myocardial contractility, inhibit sympathetic excitation, and effectively relieve ischemia; non-dihydropyridine calcium channel blockers can dilate the coronary arteries, and effectively relieve coronary artery spasm. However, it should be noted that the combination of these two drugs may lead to bradycardia and conduction block, and attention should be paid to monitoring the heart rate. Bisoprolol, metoprolol and other beta-blockers are commonly used in the clinic, and diltiazem, verapamil and other non-dihydropyridine calcium channel receptor blockers. The above drugs should be applied under the guidance of clinicians. 2. Surgical treatment: When the effect of drug treatment is not good, surgical coronary artery bypass grafting or myocardial bridge incision and release surgery can be chosen. Internal coronary stenting for myocardial bridges is still controversial and should be chosen with caution. Myocardial bridges combined with st-segment depression require hospitalization and treatment under the guidance of a physician.