It is possible for a low white globule ratio to resolve spontaneously, as seen in patients with physiologic decreases, but it is difficult to resolve a low white globule ratio that is caused by pathologic factors. The white globule ratio refers to the ratio of albumin to globulin in plasma, which is determined by the amount of albumin and globulin together. Normal people may also have a lower white globule ratio, but the amount of albumin and globulin are within the normal range, which is a physiological manifestation and can be restored to the normal range by itself. When the human body due to viral hepatitis, schistosomiasis liver disease and other pathological diseases lead to cirrhosis, the amount of albumin synthesized by the liver is significantly reduced, and the amount of albumin in the plasma is significantly reduced, which leads to a decrease in the white globule ratio. These patients are difficult to self-heal, and need to be treated for the primary disease, and the intravenous infusion of human albumin to correct the hypo-proteinemia. When malignant plasma cell diseases occur in the body, such as multiple myeloma, Hutchinson’s macroglobulinemia, and systemic amyloidosis, all of which result in markedly elevated globulin, leading to a lower white globulin ratio. These patients cannot be cured on their own and need to be treated for the primary disease in order to lower the globulin. It is recommended that patients with lowered white globulin ratio should consult the hematology department in time, complete bone marrow aspiration, biochemistry and other related tests to identify the specific cause of the disease, and then treat the specific disease.