A, miscarriage or fetal abortion, may be related to the man The wife miscarried less than two months pregnant, and the couple went to the infertility specialist hospital. Although the man expressed very still reluctance and innocence during the semen examination. And he was convinced that his wife’s miscarriage had nothing to do with him. However, the semen test results revealed that the husband’s sperm DNA fragmentation rate was as high as 65%. The male infertility specialist said that the high rate of sperm DNA fragmentation could be the culprit of his wife’s miscarriage. Because of the high rate of sperm DNA fragmentation, just like the egg yolk scattered, looks good sperm, but the internal quality of the problem, will lead to poor quality embryos, easy to miscarriage. Therefore, miscarriage is not only for women, but abnormal sperm in men can also lead to miscarriage. Examine the integrity of the sperm has a positive value in the treatment of male infertility. The DNA is located in the nucleus of the sperm and is the carrier of genetic information, similar to the yolk of an egg. Sperm-egg union, cell membrane fusion, sperm-egg chromosome assembly, and embryo development depend to some extent on the integrity of sperm DNA. Once the sperm DNA is damaged, although it appears to be “good”, its function becomes poor, and although it does not affect egg fertilization, it can easily lead to embryo failure and miscarriage. In patients with severe sperm DNA damage, even though the egg can be fertilized and divided normally, it can still lead to miscarriage in the end. 1. Affects sperm fertilization ability: Healthy sperm must have three abilities (motility, acrosome recognition, and egg recognition). If sperm DNA integrity is damaged, it will affect the egg recognition ability of the sperm, which means the loss of fertilization ability, thus leading to male infertility. 2. Causes habitual abortion: Sperm fragmentation leads to displacement of the DNA structure, which affects the development of the embryo, resulting in miscarriage, stillbirth and the birth of malformed fetuses. 3. Affects the quality of IVF: If DNA-deficient sperm is used for second-generation IVF (i.e., ICSI, intracytoplasmic single sperm injection), it can affect the development of embryonic cells and embryos as well as the health of the offspring because it bypasses natural selection. Therefore, before performing ICSI, the sperm DNA should be evaluated first. Third, male infertility should be tested for sperm DNA fragmentation rate Traditional routine semen examination can reflect semen quality in terms of sperm concentration and sperm vitality, but its value in evaluating sperm function is limited and cannot directly reflect sperm fertilization ability and impact on embryo development. The rate of sperm DNA fragmentation in men with infertility is significantly higher than that in normal subjects. Even if the other indicators of semen are normal, it does not mean that the sperm DNA fragmentation rate is normal. There are many patients with normal results of routine semen analysis who were previously diagnosed with unexplained infertility and now have been tested and found to have a high sperm DNA fragmentation rate, and after targeted treatment, they may have been given a chance to have children. Therefore, testing for sperm DNA fragmentation is very important for male infertility patients. Sperm DNA fragmentation test is suitable for: 1, infertility patients (except azoospermia patients); 2, spouses of patients with habitual abortion and embryonic abortion; 3, spouses of patients with a history of poor fertility; 4, those who voluntarily do the test for eugenics. Fourth, the rate of sperm DNA fragmentation can be reduced Under normal circumstances, sperm DNA has an implicitly defined double-stranded structure. Under certain circumstances, such as elevated testicular temperature (varicocele, etc.), environmental hormones, and heavy smoking of tobacco, etc., can lead to single-stranded as well as double-stranded sperm DNA breakage and the formation of sperm DNA fragmentation. With the proliferation of environmental hormones and increased survival pressure, sperm DNA fragmentation is becoming increasingly serious worldwide. A sperm DNA fragmentation rate (DFI) of less than 25% is normal; greater than 25% is critical; once the fragmentation rate exceeds 30%, it is abnormal and can lead to male infertility and habitual abortion. Normal sperm DNA has a double-stranded structure, but bad habits such as smoking, drug abuse, alcoholism and staying up late, long-term exposure to polluted air, high heat, toxic and radioactive work environment, reproductive gland infection and inflammation (epididymitis, orchitis, prostatitis or seminal vesiculitis, etc.), leukocytosis in semen, varicocele and other diseases are all harmful factors that lead to an increased rate of sperm DNA fragmentation. First of all, one should correct bad lifestyle habits (smoking, drug abuse, alcoholism and staying up late, etc.), regulate work stress and improve sleep quality; avoid long-term exposure to harmful environments such as high temperatures, polluted air, toxic substances and radiation exposure. Then, treatment of related physical diseases, such as the use of antibiotics for reproductive gland infections and inflammation, surgery for varicose veins, herbal or Chinese medicines, medications such as vitamin E and vitamin C, and some micronutrient supplementation treatments, also help to reduce the rate of sperm DNA fragmentation. These treatments, contribute to the success of having a healthy baby.