The usual term inflammation may refer to infectious inflammation, aseptic inflammation, and so on. The effect of inflammation leads to an upward shift in the thermoregulation point, which can cause a fever. Fever leads to a lack of oxygen to the brain, or an increase in inflammatory substances caused by the infection, which may cause a headache. Infectious inflammation is usually caused by pathogenic microorganisms such as bacteria, viruses, fungi, mycoplasmas, and chlamydia; aseptic inflammation is caused by nonbiological factors, including physical or chemical. It can produce inflammatory exudates and necrotic tissue, among other things. During the inflammatory response, endogenous thermogenic sources can be produced and released, which act on the thermoregulatory center through the blood-brain barrier, resulting in an upward shift of the thermoregulatory point. The body’s heat production increases and heat dissipation decreases, resulting in an increase in body temperature. When you have a fever, the blood vessels of the whole body dilate, and the blood vessels of the brain dilate, resulting in insufficient blood supply to the brain and lack of oxygen, causing headaches; when you have a fever, there are certain inflammatory factors in the blood circulation, which can also lead to headaches; when you have a fever, the thermoregulation point moves up, and the enzyme activity of the body decreases, which initiates the body’s autoimmune response, which can also lead to headaches. Elevated body temperature with headache, it is recommended to go to the general internal medicine department of the hospital, first to clarify the causes of elevated body temperature, and then give treatment for the primary disease.