HPV refers to human papillomavirus and the virus is divided into high-risk as well as low-risk types. When the result shows positive for HPV68, it indicates infection by high-risk type of virus. The virus is transmitted through sexual or intimate contact. It is recommended to undergo TCT in a timely manner as the disease has the potential to develop cervical cancer if not detected in time. Persistent high-risk HPV infection can be treated by vaginal placement of interferon pessary for 3 months and rechecked after 1 month of discontinuation. If HPV 68 positive is accompanied by high grade lesions in female cervical intraepithelial neoplasia, timely surgery, such as cervical lipknife circumcision or cold knife conization, should be performed. After medication or surgery to strengthen the local resistance to disease and enable the virus to be expelled, women need to be rechecked after 12 months to see if they still have HPV virus in their body. It is recommended that women pay attention to vaginal hygiene and sexual hygiene in their daily life to prevent the virus from infecting their bodies.