Metformin extended-release tablets and metformin tablets are the same kind of drug, there is no difference in efficacy, but the pharmacokinetics, the way of taking medication, etc., the use of drugs have certain adverse reactions and contraindications, should follow the doctor’s instructions for use of drugs. Metformin extended-release tablets and metformin tablets are glucose-lowering drugs, but the two are different in pharmacokinetics, dosing mode, the same dose of metformin extended-release tablets than metformin tablets peak plasma concentration is lower, but the degree of absorption is similar. Metformin extended-release tablets can be taken in a single dose, metformin tablets need to be taken in divided doses, not in a single dose. People who are allergic to metformin, severe hepatic or renal insufficiency, and severe infections should not be treated with this drug. And adverse reactions can occur with the drug, such as nausea, vomiting, diarrhea, allergy, hypoglycemia and so on. Patients who want to take Metformin Hydrochloride Extended-Release Tablets and Metformin Tablets for treatment should be under the guidance of a doctor, do not blindly use the drug by yourself.