Cranial defect is a common disorder in neurosurgery, often caused by trauma or or the treatment of brain diseases, is a kind of decompression measure to save life during surgery in the acute stage, but with the recovery of intracranial hypertension, cranial defect has no therapeutic effect, on the contrary, it will affect the recovery of neurological function after craniocerebral injury as well as cause a new functional deficit of unfavorable factors. Large cranial defects may cause serious consequences, threatening the safety of the patient’s skull and brain, affecting the appearance of the head, bringing a series of cranial defect syndrome, and also causing a great psychological shadow on the patient, so it is necessary to repair in time. A large area of cranial defect will have a great harm to the organism, causing a series of cranial defect syndrome, including dizziness, headache, limb weakness, vision loss, lack of smell, mood fluctuations, irritability, no other reason can be explained by the feeling of discomfort and a variety of mental disorders, etc.; lack of hard cranial protection, the brain will be in constant danger, by external forces or external sharp objects, it is easy to directly impact the impact of the brain tissue, and may even have a great psychological shadow on patients. Injury to the brain tissue, and may even be life-threatening; in addition, the appearance of the skull anomaly, very unattractive, will also make the patient feel inferior. We advocate early cranial repair, that is, in the cranial defects from the bulge to flat or concave on the repair, some in three months, some even in a month. Polyether ether ketone material, also known as peek material is currently one of the ideal materials for cranial bone repair surgery. peek is a kind of polymer material comparable to the human body’s own cranial bone, biocompatibility is higher, it is strong but very elastic and toughness, impact resistance is stronger, better protection performance, comfort is also higher, has a strong thermal insulation performance, there will be no hot and cold reaction sensitivity occurs; post-operative There will also be no infection, there will be no rejection; rays can be transmitted without forming artifacts. More importantly, peek is a material that can be three-dimensionally plasticized, and can be customized for three-dimensional reconstruction according to the different needs of patients. According to the patient’s brain CT data for the design, the use of 3D printing technology to produce a perfect match with the bone window of the skull after the repair of the skull and their own skull is basically no difference. However, at present, not many hospitals to peek to do skull repair, and the domestic doctors engaged in doing peek skull technology and professionalism will have higher requirements, so if the patient needs to be treated, it is recommended to choose a more authoritative hospital.