Multiple polyps in the sigmoid colon may be related to bile metabolism disorders, genetic factors, and intestinal inflammatory diseases. 1. Bile metabolism disorder: after cholecystectomy, gastroduodenal ulcer gastrojejunum anastomosis, the flow of bile and the time of discharge will be changed, and the content of bile acid in the colon will be increased, which will cause irritation to the mucous membrane, and lead to polyposis of sigmoid colon. 2. Genetic factors: Studies have found that sigmoid polyps may also be related to genetic factors. This group of people may experience loss of function and absence of an allele of an oncogene called APC in the long arm of the fifth pair of chromosomes. 3. Inflammatory bowel disease: People with chronic ulcerative colitis, Crohn’s disease, amoebic dysentery and other inflammatory bowel diseases. Long-term intestinal inflammation can cause irritation to the intestinal mucosa, may also appear in the sigmoid colon polyp. There may be other clinical causes of multiple polyps in the sigmoid colon. It is recommended to go to the gastroenterology department of the hospital as soon as possible, in order to clarify the cause of the disease and cooperate with the doctor to receive treatment, so as not to delay the condition.