The chances of anti-ro-52 antibody positivity turning negative are relatively small and it is usually difficult to turn negative. Anti-ro-52 antibody belongs to a kind of immunological examination index, generally not disease-specific, including myositis, systemic sclerosis, primary biliary cirrhosis, viral hepatitis, autoimmune hepatitis, and dry syndrome, etc. Normal people usually test negative, once the test results show positive, you can rule out one by one for the above diseases. It is recommended that patients need to go to regular hospitals to receive relevant examinations, such as ophthalmologic examination, stomatologic examination and lip gland biopsy, etc., and also need to go to the Department of Rheumatology and Immunology to receive examination of dry syndrome in order to make a clear diagnosis. In addition, immune diseases are often difficult to deal with, so it is recommended that patients need to actively receive treatment, and must not be negligent, so as to avoid delays in the condition. Consult your doctor for further treatment.