Whether a baby with thalassemia intermedia can be born depends on its gene type, clinical symptoms, prognosis and the wishes of the couple, and needs to be analyzed comprehensively. Thalassemia refers to hereditary hemolytic anemia caused by one or more kinds of impairment of the synthesis of bead protein peptide chains due to defects in the bead protein gene. According to the type of bead protein gene defects involving the bead protein chains, it is divided into several categories, commonly α and β thalassemia; and according to the clinical manifestations, it is divided into quiescent, light, intermediate, and severe types. The intermediate type of α-alpha anemia has no clinical manifestations during the fetal period, and the following clinical manifestations appear gradually after birth: the average age of onset is 4-14 years old; the severity of anemia varies greatly, and the earlier the time of onset, the more serious the condition is; except for a small number of severe cases, the basal Hb level required for growth and development can be maintained without relying on transfusion therapy, and splenomegaly is often present, and growth and development are basically normal. Beta type intermediate anemia has no clinical manifestations in the fetal stage, and after birth, different degrees of anemia begin to appear in childhood, and some of the affected children rely on regular blood transfusion to maintain their lives, and they can survive until adulthood. Whether or not a baby with intermediate anemia can be born, first of all, it is necessary to clarify the genetic category, and at the same time, consider its clinical manifestations and prognosis, combined with the wishes of both spouses, intermediate β-pearl proteins in the generation of disorders of anemia in the birth of the child, often need to spend a large amount of money on treatment for a long period of time, and the effect of the treatment is often poor, which has brought a serious burden to the family.