Menopause, refers to the perimenopausal period. Perimenopausal stomach discomfort is mostly considered to be caused by chronic gastritis, gastric ulcer, gastroesophageal reflux disease, gastric cancer and other diseases. It is necessary to clarify the cause of the disease and give medication or surgical treatment. 1. Chronic gastritis: peri-menopausal women due to gastric mucosal inflammatory reaction, the stomach’s ability to digest food decreases, gastric emptying ability is weakened, manifested as a little bit of food on the fullness, dull pain in the stomach, nausea and other symptoms of gastric distress. Need to use amoxicillin and other antibiotics to kill Helicobacter pylori treatment; take aluminum hydroxide and other drugs to protect the gastric mucosa; oral domperidone, mosapride and other drugs to promote gastric emptying treatment. 2. Gastric ulcer: perimenopausal gastric ulcer patients due to the existence of inflammatory defects in the gastric mucosa, gastric acid directly on the gastric mucosal defects, can cause epigastric burning pain, distension and other gastric symptoms. It is necessary to use drugs such as rabeprazole to inhibit the secretion of gastric acid; take gastric mucosal protective agents, such as aluminum hydroxide, aluminum thioglycollate and other drugs to promote mucosal repair. 3. Gastroesophageal Reflux Disease (GERD): Perimenopausal women will experience epigastric pain, acid reflux, nausea and other gastric symptoms due to the relaxation of the lower esophageal sphincter and reflux of gastric contents. It is necessary to use drugs such as domperidone and mosapride to promote the emptying of gastric contents; use aluminum hydroxide, calcium carbonate and other drugs to neutralize gastric acid and relieve the symptoms of acid reflux. 4. Gastric cancer: For women with recurrent stomach discomfort and progressive weight loss, gastroscopy can be performed. After diagnosing stomach cancer, surgery should be carried out in time. All the above medicines should be taken according to the doctor’s prescription. It is recommended to consult doctor in time for targeted treatment to avoid delaying the condition.