Migraine is a common clinical chronic neurovascular headache syndrome, and pharmacotherapy is the main treatment for migraine. The following drugs are commonly used in clinical practice: 1. ① Non-specific analgesics such as non-steroidal anti-inflammatory drugs and opioids: such as ibuprofen, diclofenac sodium extended-release tablets, codeine and methadone are commonly used in clinical practice, and can be used to terminate attacks in mild pain. (2) Migraine-specific treatment drugs: including treprostin, such as sumatriptan and zolmitriptan, and ergot alkaloids, such as dihydroergotamine, etc. These drugs can be used directly by moderate to severe headache sufferers to improve their symptoms as soon as possible, but it should be noted that they are powerful vasoconstrictors, which cause constriction of dilated intracranial arteries and are prohibited for patients with hypertension and cardiovascular diseases. For frequent migraineurs, antidepressants such as amitriptyline, promethazine and sertraline, beta-blockers such as propranolol, antiepileptics such as valproic acid and topiramate, and calcium antagonists such as nimodipine can be chosen according to the patient’s condition during the interictal period. In conclusion, patients with mild migraine attacks and those who respond well to nonspecific analgesics should first choose ibuprofen and diclofenac for pain management, and patients with severe headache should mostly use the above migraine-specific therapeutic drugs to terminate their attacks. In addition, patients with frequent attacks should be treated with prophylactic medications to prevent headache attacks.