In clinical practice, the presence of many disease problems may lead to a comatose state in patients, such as brain hemorrhage, brain tumor, cerebral infarction, or craniocerebral trauma. The patient may be in a coma because the cortical functions and the waking center of the brainstem have been damaged. And if there is also hydrocephalus formation at this time, it is also very troublesome. This is because when there is hydrocephalus formation, it can lead to enlargement of the patient’s ventricles and increased intracranial pressure, which can have a compressive effect on the brain tissue. So, can hydrocephalus affect a comatose patient’s wakefulness? This is a concern for many families, but it depends on the amount and severity of the hydrocephalus in the patient’s skull. For example, if the amount of hydrocephalus is too large, it may affect the patient’s heartbeat and breathing, and it may compress the brainstem, leading to brain herniation and even the risk of respiratory failure. Therefore, this may affect the patient’s awakening and requires timely surgery. If the amount of hydrocephalus is small and the effect is not significant, there is still some compensatory space after the brain is compressed, so that normal operation can be maintained, but again, attention must be paid. In other words, when a comatose patient has hydrocephalus, the family cannot be sloppy and careless. It is necessary to go to the hospital promptly through the head CT or MRI examination to understand the specific situation, and according to the professional physician’s opinion, decide whether it is necessary to arrange surgery in time to minimize the damage.