Septicothorax is often secondary to 1-2 weeks after the lung infection is relieved. Acute septicothorax can be basically disappeared on review of chest radiographs of pus after 10-12 days of closed drainage of the chest cavity, and it is usually necessary to wait for the patient’s body temperature to return to normal and then continue the treatment for more than 2 weeks. Pus chest is often caused by pneumonia, tuberculosis, lung abscess, bronchodilatation infection, etc. In the acute stage, antibacterial drugs should be applied in sufficient quantity, which can be combined with anti-anaerobic drugs, and systemically and intrathoracically administered. Drainage is also an important therapeutic tool, repeated pumping of pus and flushing of the chest cavity is conducive to reducing the patient’s systemic symptoms. If the effect of conservative treatment is unsatisfactory, acute pyothorax turns into chronic pyothorax after 6-8 weeks, surgical treatment is needed, such as pleurofibroplasty, pyothoracic pneumonectomy, thoracoplasty, etc., and appropriate surgical methods need to be selected according to the patient’s condition. In order to prevent recurrence of pyothorax, antibiotics should be applied continuously for more than 2 weeks even if the patient’s infection symptoms are controlled and body temperature is normal. In addition, nutritional support therapy is also very important, patients should be given high-energy, high-protein and vitamin-rich food, which is conducive to strengthening the patient’s body, shortening the course of the disease and early recovery. If the diagnosis of pyothorax is confirmed, the patient should consult a doctor in time and receive standardized treatment under the guidance of a physician, so as not to cause progression of the disease and affect the prognosis.