Nevi are mainly pigmented nevi, which usually do not eliminate on their own, and are benign tumors or misshapen neoplasms composed of melanocytes. Acquired nevi can be divided into junctional nevi, intradermal nevi and mixed nevi, which usually do not need special treatment if they do not affect aesthetics much. However, some nevi may become malignant and transform into melanoma, which requires timely treatment to avoid metastasis. At present, there is no specific drug for the treatment of moles, but mainly surgical treatment and physical therapy are used. Surgical treatment is for pigmented nevi, sebaceous nevi, and epidermal nevi, and there is a higher risk of scarring after surgery because part of the normal skin is cut off during excision. In addition, physical treatments are also available, such as laser mole removal and frozen liquid nitrogen mole removal. This method is suitable for moles located in the superficial layer and requires multiple treatment sessions, and also has the risk of recurrence, so patients are advised to choose at their discretion. When moles rapidly increase in size, deepen in color, and become itchy, ulcerated, and painful, they are considered to turn into melanoma, which needs to be removed in time, while other moles can be removed or not by patients’ choice. Each person has his or her own characteristics and having a mole is not a disadvantage. If you need to get rid of it, you can choose the right way for yourself under the advice of your doctor.