A high activated partial thromboplastin time is indicative of coagulation factor deficiency and possible bleeding tendency. Activated partial thromboplastin time, abbreviated as APTT, is an indicator of the endogenous coagulation system and reflects the normal function of various endogenous coagulation pathways. A high activated partial thromboplastin time often indicates the possible presence of liver disease, obstructive jaundice, impaired coagulation factor synthesis due to malabsorption, etc.; or the possible presence of genetic-related diseases such as hemophilia; or an enhanced fibrinolytic system resulting in abnormal coagulation; or the patient’s use of anticoagulant drugs, etc.; as well as the patient’s possible presence of rheumatic immune system diseases such as lupus erythematosus, etc. In addition, patients with high prothrombin time in the activation part should also pay attention to avoid trauma, which may cause massive bleeding, and should also visit the hematology department as early as possible to achieve early diagnosis and treatment to avoid delaying the disease.