Children with precocious puberty are likely to have premature bone development and early epiphyseal closure before they reach developmental age, resulting in a generally short adult size. The epiphysis is a secondary center of ossification that occurs at different times after birth, and the epiphysis and epiphyseal plate are the growth areas of the immature long bones of the limbs, which are also the weakest and most fracture-prone parts of the bones of children. In precocious puberty, females show breast development, enlargement of labia minora, estrogen-dependent changes in vaginal mucosal cells, enlargement of the uterus and ovaries, appearance of pubic hair, and first menstruation. Males show enlarged testicles and penis, appearance of pubic hair, developed muscles, and thickened voice. Both men and women have accelerated growth and accelerated bone maturation, which can eventually lead to lifelong height below the target height. In the presence of central nervous system lesions such as intracranial tumors, headache, vomiting, vision changes or other neurological signs and symptoms may be present. So, how can premature epiphyseal closure be prevented? The following check introduces preventive measures for premature epiphyseal closure: 1. To prevent the occurrence of precocious puberty, parents should also pay attention to giving their children less chicken, beef, mutton, silkworm chrysalis, etc., and not to abuse so-called children’s food that has not been strictly tested. 2, do not give children indiscriminate nutritional supplements, such as royal jelly, pollen preparations, chicken embryo and other “tonic”, proper storage of contraceptive drugs, breast enlargement beauty products, etc., so that children do not accidentally take or contact. 3, early detection, timely treatment. In addition to the necessary medical knowledge, parents should pay more attention to observe whether the child has premature appearance of secondary sexual characteristics, children under 10 years of age suddenly accelerated height growth and other phenomena, once the discovery of abnormalities, should be promptly to the regular hospital for medical treatment. 4. Children with precocious puberty should be educated about menstruation and menstrual hygiene, and sex education should be started early according to the child’s comprehension.