What should I do about the nerve pain on one side of my lower back? The nerve pain on one side of the lower back should be treated according to the cause of the nerve pain. If the neuralgia on one side of the waist is accompanied by pain in the hip or thigh on the same side or pain in the lateral calf, it is considered that there may be lumbar disc herniation, and at this time, treatment can be given to lumbar massage, lumbar physiotherapy, or oral medication, such as Prevacid, gabapentin, etc. If the above treatment measures are not effective, local closure of the waist can be carried out for treatment. If the neuralgia on one side of the waist is caused by herpetic neuralgia due to herpes zoster, the main treatment is to give anti-viral, anti-inflammatory and nerve nourishing treatment for herpes, and at the same time, oral pain medication can be administered to deal with it.