Crohn’s disease (Crohn’s disease) is very similar to intestinal tuberculosis in terms of clinical manifestations and pathological changes, which often leads to misdiagnosis, even with biopsy, and should be brought to the attention of clinicians. The main differences between the two diseases: (1) patients with intestinal tuberculosis are often complicated by pulmonary tuberculosis; (2) incomplete intestinal obstruction, intestinal fistulas and organ abscesses caused by Crohn’s disease are more common than intestinal tuberculosis; (3) Crohn’s disease has a long course and anti-tuberculosis treatment is ineffective; (4) both intestinal tuberculosis and Crohn’s disease are most common in the ileocecal region, but shortening of the ileocecal region is more common in intestinal tuberculosis on X-ray, while Crohn’s disease is less common. Endoscopic examination of intestinal tuberculosis mostly shows circular ulcers, while Crohn’s disease mostly shows longitudinal ulcers; ⑤ biopsy of intestinal tuberculosis tissue shows caseous necrotic granulomas or tuberculosis bacilli, while Crohn’s disease shows granulomatous changes without caseous necrosis and tuberculosis bacilli.