2012 domestic expert consensus of the recommended eradication program of H. pylori: 1, eradication program composition recommended bismuth + PPI + 2 kinds of antibacterial drugs composed of quadruple therapy: 4 composition program: (1) amoxicillin + clarithromycin; (2) amoxicillin + levofloxacin; (3) amoxicillin + furazolidone; (4) tetracycline + metronidazole or furazolidone. Among these 4 antimicrobial composition regimens, 3 antimicrobial drugs that are prone to resistance after treatment failure (metronidazole, clarithromycin and levofloxacin) belong to different regimens respectively, and only amoxicillin and furazolidone, which are not easily resistant, have duplication. The advantages of these regimens are: they all have a relatively high eradication rate; after the failure of any one regimen, another regimen can be chosen even without drug sensitivity testing. Regimens (3) and (4) are stable and inexpensive, with a potentially slightly higher incidence of adverse effects; regimen (1) has a low incidence of adverse effects and the cost depends on the choice of clarithromycin; regimen (2) has a cost and incidence of adverse effects depending on the choice of levofloxacin. 2. The recommended antimicrobial composition scheme for penicillin allergic patients is: (1) clarithromycin + levofloxacin; (2) clarithromycin + furazolidone; (3) tetracycline + metronidazole or furazolidone; (4) clarithromycin + metronidazole. The dosage and administration of antimicrobial drugs in the composition regimen is the same as that of the regimen containing amoxicillin. It should be noted that after failure of initial treatment in penicillin-allergic patients, the choice of antimicrobial drugs is small and the eradication rate of initial treatment should be increased as much as possible.