When she was young, Ms. Zhu failed several times in dating and blamed a “tear mole” at the corner of her eye, so she painfully removed the mole below her eye. In the following 20 years, she repeatedly removed the mole with laser, and recently, she was found to have cancer in the hospital. Ms. Zhu is 57 years old and lives in East-West Lake. When she was born, she had a mole under the right corner of her eye, which was only 4mm in size. When she came to the age of marriage, she started to notice this mole in the corner of her eye because several blind dates failed because the man’s family thought she had a “tear mole” and would have a bad life in the future. Finally, she went to a beauty salon to have it removed with laser. She didn’t expect that the mole would appear again 10 years later, and she couldn’t get rid of it even after several times of laser removal. In the last two years, this mole gradually grew to the size of a soybean. Yesterday, she went to the hospital for surgery to remove it. The doctor took a closer look and found a brown crust in the center of the mole, suspecting that it was not an ordinary mole. When the pathology result came out, it confirmed the doctor’s suspicion that the mole had become cancerous and was diagnosed as basal cell carcinoma. Ms. Zhu was shocked to hear this news. After asking about the condition, the doctor speculated that the laser might have stimulated the mole cells, and since the mole cells could not be removed cleanly and easily brought to the deep dermis, they might be transformed into malignant and developed into skin cancer. The doctor introduced that basal cell carcinoma, which mostly occurs on the face, is a low-grade malignant tumor that needs to be surgically removed. The mole itself is benign, but the chance of malignant transformation increases after external stimulation in some parts of the mole. Which moles are not suitable for laser removal? Doctors introduce that moles near mucous membranes, mouth and private parts are not recommended to use laser. If the diameter of the mole is more than 3 mm, or repeated laser removal is not clean, further laser is not recommended. Direct weight-bearing friction on the palms of hands and feet can easily cause malignant melanoma, and it is best to take surgery to remove them. Once a mole is significantly enlarged, deepened in color or locally ulcerated, it is important to consult a doctor as soon as possible.