Toenails with pus may be caused by onychomycosis, ingrown nails, trauma and other reasons, can be treated by oral medication or applying medication. 1. Inguinitis: the disease will lead to the destruction of the skin around the nail caused by inflammation, with the prolongation of the disease will appear the phenomenon of pus, resulting in pus in the toenail, you can take amoxicillin clavulanate potassium tablets, cefixime dispersible tablets and other drugs to treat. 2. ingrown toenail: usually occurs in the bunion, after the disease will be embedded in the nail edge part of the soft tissue around the nail groove caused by infection, so as to secrete pus secretion. You can apply neomycin fluoride cream, erythromycin ointment and other drugs to treat it. 3. trauma: toenail if the smash or wear shoes improper trauma, may lead to the nail bed or the surrounding soft tissue damage, thus causing the phenomenon of toenail pus, you can apply povidone-iodine, gentamycin hydrochloride ointment and other medications. Toenail pus can not be ruled out is caused by fungal infection, the patient can not apply drugs privately, or privately through other ways of treatment, need to timely medical treatment under the guidance of the doctor to use drugs.