The patient was female, 44 years old. She was transferred to our hospital from overseas with abdominal pain and abdominal distension for 1 month, with difficulty in walking for 3 days. The colonoscopy showed that the intestinal cavity was obviously narrowed and it was difficult to pass the colonoscope. CT showed multiple metastases in the right lobe of the liver and suspicious metastases in the left lobe, and numerous lymph nodes in the mesentery were enlarged. At the time of admission to our hospital, the patient had difficulty in straightening his back, mild swelling and pain in his right thigh, and the next day it was clearly identified as deep vein thrombosis in the right lower limb. After 5 weeks, the patient was able to walk on his own, and ultrasonography showed no significant thrombosis in the deep veins of the lower extremities; abdominal CT review showed multiple metastases in the right lobe of the liver, a significant reduction in the mesenteric lymph nodes, and no thrombosis in the intrapelvic veins; colonoscopy showed The CT of the lung vessels suggested thrombosis in some of the lung vessels. In the 6th week after admission, an open abdominal exploration under general anesthesia revealed no clear metastatic nodes in the left half of the liver, a 6*5 cm hard mass in the middle right of the transverse colon, and enlarged lymph nodes in the mesentery, and no obvious metastases in the rest of the body. Therefore, the right hepatic artery and the right branch of portal vein were dissected first; then an enlarged right hemicolectomy was performed to complete the anastomosis between the terminal ileum and the splenic flexure of the colon; finally, the right hemicolectomy was performed in a regular manner. Postoperative pathology confirmed liver metastasis of colon adenocarcinoma and 4/56 metastasis of lymph nodes. The patient had a good postoperative recovery and had been monitoring coagulation and using anticoagulant drugs, and continued chemotherapy in the postoperative month.