The second joint pain in the big toe can be caused by the following reasons: first, gout, gout most often involves the joint of the big toe, which can have joint pain, accompanied by swelling, skin redness and swelling, and in severe cases, gout stones may form. Second, infectious diseases, when the joints of the big toe are infected with bacteria or tuberculosis, there can be joint pain, joint swelling and skin redness, then blood tests, pathogenic tests and X-rays of the toe, MRI to diagnose and treat. Thirdly, rheumatism and rheumatoid diseases can also cause pain in the joints of the big toe, which can be accompanied by swelling and deformity, and blood tests and X-rays of the foot are needed for early diagnosis and treatment.