Skull defects are usually caused by traumatic brain injuries and internal brain lesions, which are often caused by traffic accidents, natural disasters, and heavy objects. Lesions of the skull itself are commonly caused by cerebral hemorrhage and cerebral infarction, which may leave a cranial defect after emergency debridement surgery. Long-term cranial defects are extremely harmful to the patient’s health and psychology. In some patients, the defects may appear as depressions or bumps, causing a series of cranial defect syndromes, which pose a serious threat to the patient’s health, and at the same time traumatize the patient’s psychology due to the extremely unattractive appearance. Neurosurgical guidelines clearly indicate that cranial defects of 3cm*3cm or more should be repaired as soon as possible when the patient’s condition is stabilized. Although cranial bone repair surgery in most general hospitals can be carried out, but because the operation involves the human scalp, blood vessels, brain tissue, nerves and other important organs, but also found that there are patients with postoperative rejection of infection and other discomforts, so the patient should not be taken lightly, we must choose advanced and mature cranial bone repair technology. It is reported, polyether ether ketone peek cranial bone repair plastic surgery, with new high science molecular peek do implant material, take embedded repair way, smooth articulation after surgery, strong resistance to hit, rejection infection rate is low. At the same time, we carry out personalized optimization of material design and surgical technology innovation and upgrading, the introduction of the concept of cosmetic plastic surgery, for each patient to develop a personalized cranial repair and appearance of plastic surgery program, to ensure that the postoperative precision repair, the shape of the two sides of the symmetry of the natural and beautiful. The cost of cranial bone repair actually needs to be considered according to the size of the defect area, the difficulty of the surgery, the presence of other comorbidities, the specific treatment and care, and other factors.