The word “fire” is a household word in China, especially in the southern region, the weather is hot, as long as the mouth ulcers, the people think they are eating “hot” food “on fire”. The “herbal tea” should be good. In fact, when there are oral ulcers, and repeatedly do not heal, should be careful of an easy to ignore the disease “leukoplakia”. Leukoplakia is a common rheumatic disease, belonging to the category of systemic vasculitis, its most common manifestation is repeated oral ulcers, at least 3 episodes per year, when accompanied by vulvar ulcers and skin nodules erythema, stubborn folliculitis should be extra careful about the possibility of the disease, the disease is best in the 20-40 year olds, especially in China to men, women and the elderly can also develop. In addition to ulceration of the oral mucosa and skin as the main manifestation, leukoaraiosis can also manifest as joint swelling and pain, fever, etc. But most importantly, it can involve all major organ systems of the body, such as the eyes, which can lead to sudden blindness due to iridocyclitis. In addition, damage to the internal organs is more insidious and cannot be detected early. For example, the heart may show severe regurgitation of the aortic valve and be forced to undergo surgery, only to fail due to repeated perivalvular leaks; the lungs may show pneumonia or pulmonary solids; and the large arteries may show pseudoaneurysms, thrombosis or bleeding of organs, or thrombosis of veins, which is the vascular type and is an important factor in death. The neurological type and the gastrointestinal type are the other two types, which show neurological damage and total gastrointestinal erosion, ulceration, bleeding or even hemorrhage and intestinal perforation, respectively. These types are easily mistaken by patients and primary care physicians as general headache, acute gastroenteritis, acute appendicitis, etc. because of their very insidious onset and rather non-specific clinical manifestations. When the condition deteriorates further, the best time for treatment is missed. When the gastrointestinal tract is perforated and bleeding profusely, the lesion often has to be treated by emergency surgical excision, but without basic treatment with anti-rheumatic drugs, it often fails soon after surgery, with a high risk of rebleeding and reoperation and further deterioration of the patient’s prognosis. Studies have shown that male patients, recurrent disease recurrence and arterial involvement are important risk factors for death. Many internists and patients often ask what tests are done to confirm the diagnosis of leukoaraiosis. Unfortunately, no tests are specific for the diagnosis of leukoaraiosis, and the disease still relies on the rheumatologist to make a diagnosis after combining the patient’s condition and all ancillary tests and excluding other diseases. The treatment plan also follows the principle of individualization and is based on a combination of the severity of the patient’s condition and organ involvement. Therefore, leukoaraiosis requires close collaboration among multidisciplinary doctors, which involves dentistry, gastroenterology, neurology, respiratory medicine, cardiology, cardiac surgery, gastrointestinal surgery, oncology and general internal medicine, etc. People should also learn more about medical science, and patients with similar diseases should be alert to changes in their own conditions and seek medical consultation in a timely manner, and suspected patients should go to the rheumatology department as soon as possible for early detection and treatment. The vast majority of patients have a good prognosis as long as they are treated regularly.