Polypoidal choroidal vasculopathy (PCV) is a specific type of macular lesion. It is a lesion of the intraocular blood vessels that manifests itself primarily as an enlargement of the choroidal branching vascular network and the ends of the vascular network. These abnormal vascular networks and dilated blood vessels are unhealthy and tend to leak fluid or even blood outward, causing severe vision loss due to fundus hemorrhage and retinal edema in patients. Orange lesions in the fundus, plasmacytosis or hemorrhagic retinal pigment epithelial detachment can be found during the examination by an ophthalmologist. Treatment of PCV is most effective with photodynamic therapy (PDT) guided by indocyanine green fundus imaging (ICGA), which effectively seals the polypoid lesion and slowly absorbs the hemorrhage and exudate, but when treating PCV with extensive lesions with PDT, one should be alert to possible complications subretinal hemorrhage and/or vitreous hemorrhage. In cases treated successfully with PDT, attention should also be paid to regular follow-up observations to detect new polypoid lesions in a timely manner and provide aggressive treatment. The current main treatments for PCV are briefly summarized as follows: PDT alone: effective in closing polypoid lesions, some require multiple treatments PDT + Lucentis, an anti-neovascular drug: fast vision improvement and reduced number of PDTs, but Lucentis is also very expensive PDT + Avastin, an anti-neovascular drug: fast vision improvement and reduced number of PDTs, but the use of Avastin is limited PDT + dexamethasone + anti neovascular drug: fast vision improvement, reduce the number of PDT, but Lucentis is also expensive PDT + dexamethasone: faster vision improvement, slightly better than PDT alone PDT + tretinoin: fast vision improvement, reduce the number of PDT, but prone to glaucoma, cataracts Anti neovascular drug alone: need Multiple injections, only reduce exudative edema, not eliminate lesions Fundus hemorrhage, orange lesions, severe vision loss Polyp-like lesions (white mass shadows) can be seen on angiography