At present, the most advanced treatment plan for syphilis in China and abroad, in fact, is still the application of penicillin treatment, the clinical first choice is long-acting penicillin, such as benzathine penicillin, procaine penicillin G, aqueous penicillin G. Benzathine penicillin, generally is used 2.4 million units, divided into two sides of the buttocks intramuscular injection, once a week intramuscular injection, three times is considered a course of treatment. Procaine penicillin G, is 1.2 million units intramuscular injection, once a day intramuscular injection, continuous application for 10-14 days. At present, domestic and foreign for the treatment of syphilis, there is no introduction of any more advanced treatment options, check the relevant syphilis treatment guidelines are not proposed. Only when there is an allergy to penicillin, ceftriaxone, tetracyclines, macrolides can be chosen as an alternative.