In clinical practice, the use of antibiotics for patients with acute mastitis is very strictly required. Patients are usually advised to use penicillin for treatment, which is generally very effective in the clinical treatment of acute mastitis. However, if the patient is allergic to penicillin, erythromycin can be used. It is important to note that if the patient is a breastfeeding patient with acute mastitis, the use of antibiotics must be strict and cautious, and the patient should not be treated with aminoglycosides and metronidazole, as these drugs tend to have a bad effect on the baby. Therefore, patients with acute mastitis must be cautious in the use of these antibiotics. The prognosis for patients with acute mastitis is generally good with active anti-infection treatment; however, if the patient’s acute mastitis is not well controlled and develops into an acute breast abscess, active surgical treatment is required for a good recovery.