In general, the early signs of AD onset include memory impairment (mainly near memory impairment), inability to complete familiar tasks and work, language impairment (e.g. forgetting simple words, inability to express one’s wishes correctly, etc.), confusion about time and place, reduced judgment (e.g. dressing indiscriminately regardless of the season), abstract thinking skills, frequent misplacing of things, behavioral and emotional changes, personality changes The early diagnosis of Alzheimer’s disease can be made in a number of ways. How to diagnose Alzheimer’s disease early In addition, we can also use MRI to evaluate the atrophy of medial temporal lobe structures, positron emission tomography (PET), imaging marker age spot developer (18F-FDDNP) and Pittsburgh Compound-B (PIB) for early diagnosis. Genetic tests for ApoE genotype, such as E4 with early symptoms are important for diagnosis. There are also applications of scales for early diagnosis of AD, such as the Preclinical AD Cognitive Load Scale (ADCS-PACC), which is able to assess situational memory, time-limited executive function, and overall cognitive function, the significance of which has yet to be determined.