High blood creatinine but no urine protein can be seen in acute kidney injury, some chronic kidney disease, or physiological conditions such as muscular athletes. 1. Acute kidney injury, especially pre-renal and post-renal triggers, such as severe vomiting, diarrhea caused by blood volume deficiency, renal blood flow caused by the corresponding reduction; urinary stone obstruction in the early stage, may be manifested as elevated blood creatinine, proteinuria negative. 2. Chronic kidney disease, especially chronic tubulointerstitial injury, such as hypertension caused by benign renal arteriolar sclerosis, invading the small arteries in front of the glomerulus, resulting in tubular stenosis, reduced blood supply and resulting in decreased renal function; gouty nephropathy, urate deposition, resulting in tubular obstruction caused by creatinine elevation. In the above mentioned diseases, proteinuria is less, or even negative proteinuria. 3. Physiological conditions, such as strenuous exercise, muscular athletes, etc., can be manifested as elevated creatinine, proteinuria negative, at this time there is no need for special treatment, pay attention to rest, regular review can be. When the cause is not clear, you can improve the renal puncture biopsy, clear cause, for specific causes of standardized treatment. For those who have high creatinine but no proteinuria, it is recommended to go to regular hospitals to find out the cause of the problem and get treatment under doctor’s guidance.