A pimple on the face that is painful to touch may be caused by acne, folliculitis, seborrheic dermatitis and other diseases, which need to be treated according to the cause. 1. Acne: Related to abnormal androgen levels, sebum from the sebaceous glands cannot be discharged normally, clogging the pores can cause acne, which can be painful. It can be treated with medications such as fusidic acid cream, clindamycin ointment and benzoyl peroxide gel. 2. Folliculitis: Facial hair follicles are infected with bacteria and are prone to red pimples, which can be painful. You can apply erythromycin ointment, mupirocin ointment and other drugs, but also need to pay attention to skin cleanliness, after sweating in time to dry. 3. Seborrheic dermatitis: related to Malassezia infection, easy to cause the patient’s skin lesions will also grow red pimples, and accompanied by severe pain. Itraconazole capsules can be taken orally, and apply clotrimazole cream and other antifungal drugs treatment. There may be other reasons for a pimple on the face that is painful to touch, so it is recommended that the patient go to the hospital to get a clear picture of the cause of the disease and follow the doctor’s instructions to treat the cause of the disease.