Difficulty in gasping for breath with chest tightness and distension is mainly considered to be caused by abnormal cardiopulmonary function, and the common causes include coronary heart disease, myocarditis, heart failure, pneumonia, chronic bronchitis, asthma and lung cancer. 1. Coronary heart disease: mainly due to coronary artery stenosis causing insufficient blood supply to the myocardium, resulting in corresponding symptoms, some of which may be accompanied by crushing pain. 2. Myocarditis: most of them are induced by upper respiratory tract infections, and after myocardial damage occurs, it affects the heart function and further leads to corresponding symptoms. 3. Heart failure: mainly due to the abnormal pumping function of the heart, which further leads to pulmonary edema and related symptoms, and the symptoms will be aggravated after exertion, and there will be the performance of sitting breathing. 4. Pneumonia: Bacterial, viral, mycoplasma and other infections will lead to inflammation in the lungs, resulting in exudation and solid changes in the lungs, which will cause corresponding symptoms, and some of them will be accompanied by fever. 5. Chronic bronchitis: the condition of small airways is abnormal for a long time, which affects the function of ventilation and air exchange and causes corresponding changes. 6. Asthma: there is a correlation between various airway metabolic reactions, and small airway spasms will occur and cause related symptoms. 7. Lung cancer: Lung cancer directly causes bronchial compression or damage, resulting in narrowing and blockage, leading to corresponding symptoms, partly accompanied by chest pain and hemoptysis. There may also be other reasons, such as cardiac arrhythmia, pneumothorax, reflux esophagitis, aortic coarctation, which may cause related symptoms. It is recommended to go to the hospital in time for medical consultation, and give targeted treatment or therapy after completing the examination and clarifying the cause of the disease.