1.Significant loss of appetite: abdominal stuffiness and distension, indigestion, sometimes nausea and vomiting. 2. Liver pain: There may be persistent or intermittent pain in the liver area, sometimes aggravated by changes in position. It may radiate to the back or right shoulder. Severe abdominal pain and peritoneal irritation may occur suddenly in advanced liver cancer, which may be caused by necrosis of cancer nodes or bleeding into the abdominal cavity. At this time, patients often go to the emergency room with the manifestation of acute abdomen. 3. Systemic failure: severe weakness, emaciation, progressive anemia and edema. 4.Jaundice, ascites and itchy skin: are common symptoms of liver cancer. About 1/3 of the cases have jaundice during the course of development. The reason for jaundice is that the cancer invades the main bile ducts in the liver and the metastatic cancer in the hilar lymph nodes compresses the extrahepatic bile duct. Ascites is often caused by the patient’s pre-existing cirrhosis, the invasion of cancer tissue into the veins and the formation of cancer thrombi, and the compression of the portal vein by cancer nodes. Ascites often accumulates very quickly and can be straw-yellow or blood-colored. Itchy skin is a common symptom of liver disease and liver cancer patients.