Thickening of the small bowel wall is usually a pathologic change detected on CT or colonoscopy. This finding alone is not sufficient to diagnose the disease or determine its severity, and further testing is needed to determine the exact cause of the disease. Partial thickening of the small bowel wall may be due to parasitic infections, inflammation, small bowel polyps, or tumors. If it is caused by parasitic infection or inflammation, it can be treated conservatively, but if it is caused by polyps, it is usually more serious and may require surgery. Intestinal parasitic infections, patients may have diarrhea, abdominal pain and other symptoms, can be prescribed oral albendazole, mebendazole and other drugs. Part of the thickening of the wall of the small intestine may be caused by inflammation of the small intestine, through the application of levofloxacin, amoxicillin and other antibiotic treatment, can effectively promote the recovery of inflammation of the small intestine. If it is caused by polyps, tumors, with a certain tendency of cancer, patients may have abdominal pain, black stools, loss of weight, weakness of the limbs and other symptoms. Diagnosed as intestinal polyps, surgical resection under colonoscopic conditions is sufficient; if there is malignant lesion, the condition is serious and usually requires active surgery, radiotherapy, chemotherapy (e.g. 5-FU, mitomycin, etc.) and other treatments. Part of the thickening of the wall of the small intestine, you should consult the doctor in time, further improve the relevant examination, clarify the cause of the disease, and then follow the doctor’s instructions for treatment. Patients should not blindly self-judgment, so as not to delay the condition.