Taking vitamin B6 for seborrheic dermatitis, is effective, but taking vitamin B12 is not. Vitamin B12 and vitamin B6, both belong to one of the vitamin B drugs. Among them, vitamin B6 can play a role in reducing the sebaceous glands secretion of oil, so for seborrheic dermatitis has a certain therapeutic effect. However, for seborrheic dermatitis, it is mainly considered to be related to Malassezia infection, abnormal sebum level and immune response, etc. Clinically, it is mainly treated by removing sebum, anti-inflammatory, antiseptic and anti-itching. According to the patient’s needs, the treatment can be applied externally or taken internally, such as external hormone ointment (mometasone furoate), calcium-modulated phosphatase inhibitor (pimecrolimus), selenium disulfide lotion and other drugs. At the same time can be combined with oral vitamin B6, zinc and so on. So once the seborrheic dermatitis, we should pay attention to timely to the hospital, under the guidance of the doctor for reasonable treatment. Drugs need to be used in accordance with medical advice.