Cervical cancer stage 3b squamous carcinoma can be treated with simultaneous radiotherapy, targeted drugs and immunotherapy. Stage 3b squamous carcinoma of cervix often belongs to locally advanced stage, which indicates that the lesion is relatively large with invasion of surrounding tissues. Surgery for this kind of patients is often unable to remove the lesion completely, so surgical treatment is not chosen. Cervical squamous carcinoma has better sensitivity to both radiotherapy and chemotherapy, and synchronized radiotherapy and chemotherapy can be chosen. Chemotherapy is often a two-drug combination regimen, and commonly used chemotherapy regimens include cisplatin + 5-fluorouracil or single-drug cisplatin weekly regimen. In advanced cases, extracorporeal radiation is the mainstay, and intracavitary radiotherapy is supplementary. In principle, extracorporeal irradiation and intracavitary irradiation are used in parallel. Currently, bevacizumab is the most widely used drug for targeted therapy of cervical cancer, which can inhibit neovascularization and slow down tumor growth and metastasis. Immunotherapy such as pembrolizumab can also be used if eligible. It is recommended that patients choose the appropriate treatment method according to their own conditions under the guidance of doctors and actively treat the disease to avoid delaying the condition.