Lymphoma rash is often characterized by chronic recurrent cutaneous macules and nodules with unclear borders. Lymphoma is a relatively common hematologic malignant tumor in clinic. Lymphoma of the skin can be manifested as macular rash and localized nodules, especially multiple lumps with unclear boundary with the surrounding, which are often combined with clinical symptoms such as fever, emaciation, anemia, etc., and some of the patients may be accompanied by localized skin ulceration phenomenon. After clear diagnosis, treatment should be chosen according to the condition, usually including surgical resection or radiotherapy. Pathological examination is the gold standard for the diagnosis of lymphoma, and it is also able to further classify lymphoma and guide the choice of treatment plan for patients. Therefore, lymphoma rash is characterized by patchy rash and nodules, and biopsy of the lesion can clarify the diagnosis and guide the treatment.