Recently, we successfully treated a patient with stab wounds to the inferior vena cava combined with pancreatic stab wounds. The patient had been stabbed several times and was in shock upon admission with blood pouring from the abdomen. Intraoperative exploration revealed that the patient had received several stab wounds, almost fatal, one of which caused a penetrating injury to the inferior vena cava and one of which caused a penetrating injury to the pancreas. The head of the pancreas was severed and one cut caused gallbladder penetration, and the patient’s abdominal cavity was filled with blood and bile. We decided to repair the inferior vena cava first and perform pancreaticoduodenectomy in one stage at the same time. The operation lasted 4 hours, and the patient lost a total of 10,000 ml of blood, and the operation was successful. After the surgery, after 20 days of recovery, the patient was discharged successfully without complications such as pancreatic fistula. The repair of inferior vena cava penetration injury under shock reflects the technical level of our vascular surgery team, while the one-stage pancreaticoduodenectomy reflects the excellent skills and extraordinary courage of our hepatobiliary surgery team.