11.2.1 Non-small cell lung cancer treatment options
11.2.1.1 Adjuvant chemotherapy regimen
Cisplatin: 75mg/m2, intravenous drip, day 1 (or total amount given in 3 days)
Vincristine: 25mg/m2, intravenous drip, day 1, 8
Repeat every 21 days for 4 cycles of chemotherapy
Cisplatin: 100mg/m2 intravenously on day 1
Etoposide: 100mg/m2, intravenous drip, day 1, 2, 3
Repeat every 28 days for a total of 4 cycles of chemotherapy
Cisplatin: 80mg/m2 intravenously on day 1
Vincristine: 4mg/m2, intravenous injection or intravenous flush, day 1, 8, 15
Repeat every 21 days for a total of 4 cycles of chemotherapy
The purpose of adjuvant chemotherapy is to reduce the risk of recurrence and metastasis. Adjuvant chemotherapy still has adverse effects, and the pros and cons of treatment should be fully evaluated, and adjuvant chemotherapy should be used with caution in patients with poor general physical condition after surgery.
11.2.1.2 Simultaneous chemotherapy and radiotherapy treatment plan
Cisplatin: 50mg/m2, intravenous drip, day 1 and 8
Etoposide: 100mg/m2, intravenous drip, day 1 to 5
28 days for 1 course of treatment, simultaneous chest radiotherapy
Cisplatin: 100mg/m2, intravenous drip, day 1, 39
Vincristine: 5mg/m2, intravenous injection or intravenous flush, once a week ´ 5 times
Simultaneous chest radiotherapy.
Paclitaxel: 45-50mg/m2, intravenous drip for 1 hour, once a week
Carboplatin: 200-400 mg/m2 or AUC = 2, IV drip over 0.5 hours, once every 4 weeks
Simultaneous chest radiotherapy.
11.2.1.3 Chemotherapy regimen for advanced non-small cell lung cancer
Vincristine: 25 mg/m2, intravenous drip, days 1 and 8
Cisplatin: 75 mg/m2, IV drip, day 1 (or total given over 3 days)
Anti-angiogenic drugs may be added as appropriate, repeated every 21 days, usually 4-6 cycles of chemotherapy
Gemcitabine: 1000-1250mg/m2, intravenous drip, day 1 and 8
Cisplatin: 75mg/m2 intravenously on day 1 (or total amount given in 3 days)
Anti-angiogenic drugs may be added as appropriate, repeated every 21 days, generally 4-6 cycles of chemotherapy
Docetaxel: 60-75mg/m2, intravenous drip, day 1
Cisplatin: 75mg/m2 IV on day 1 (or total amount given over 3 days)
Anti-angiogenic drugs may be added as appropriate, repeated every 21 days, usually 4-6 cycles of chemotherapy
Paclitaxel: 135mg/m2, intravenous drip, day 1
Carboplatin: 200-400mg/m2 or AUC=5-6, IV drip for 0.5 hours, day 1
Anti-angiogenic drugs can be added as appropriate, repeated every 21 days, generally 4-6 cycles of chemotherapy
Chemotherapy for patients with advanced lung cancer is a palliative treatment, and the pros and cons of chemotherapy should be fully evaluated to prevent overtreatment. Factors such as the patient’s pathological type, development trend, and the patient’s physical condition should be considered in treatment.
11.2.1.4 Second-line treatment regimen
Second-line chemotherapy regimens
Docetaxel: 60-75 mg/m2 intravenously, day 1
Repeat every 21 days
Pemetrexed: 500mg/m2 intravenously, day 1
Repeat every 21 days
Second-line molecular targeted therapy regimen
(1) Gefitinib: 250mg/day, orally
(2) Erlotinib: 150mg/day, orally
11.2.1.5 Chemotherapy regimens for advanced non-small cell lung cancer in the elderly and poor general condition (PS = 2)
(1) Vincristine: 25mg/m2, intravenous flush, days 1, 8 and 15, repeated every 28 days, for a total of 4-6 cycles of chemotherapy.
(2) Gemcitabine: 1000mg/m2, intravenous infusion, day 1, 8, 15, repeated every 28 days, total 4 to 6 cycles of chemotherapy.
(3) Paclitaxel or docetaxel treatment, repeated every 28 days for a total of 4 to 6 cycles of chemotherapy.
The treatment of elderly patients should be grasped to prevent the harm caused to patients by over-treatment.