When gastritis with chest pain occurs, gastroesophageal reflux disease or reflux esophagitis is considered. When the sphincter of the lower esophagus or the cardia is dysfunctional, the acid reflux from the esophagus to the esophagus is impaired, and chest pain, heartburn, acid reflux, and burning sensation behind the sternum may occur. In addition to gastritis and reflux esophagitis, chest pain should be differentiated from acute myocardial infarction and coronary artery disease. If a patient with hypertensive base develops chest pain, an electrocardiogram should be performed promptly to observe ST-T changes in the electrocardiogram, as well as significant elevation of myocardial enzyme profile and myocardial calcium troponin. Gastroscopy can further understand the grading of reflux esophagitis and the severity of chronic gastritis.