Chronic leukemias are neoplastic myeloproliferative disorders. Among them, chronic granulocytic leukemia (slow granulocytosis) is a malignant proliferative disease caused by the production of abnormal clones of ph chromosomes in hematopoietic stem cells, unrestricted production of large numbers of naive blood cells, especially granulocytes, in the bone marrow, and accumulation of large numbers of naive and mature granulocytes in the peripheral blood. Chronic lymphocytic leukemia (CLL) is a generalized malignant proliferative disease involving small lymphocytes and lymphoid tissues, with large accumulations of lymphocytes in the bone marrow, spleen, liver, superficial and deep lymph nodes throughout the body, as well as in the walls of the respiratory and digestive tracts. In China, chronic gonorrhea is common, often occurring in middle-aged people, and currently there is a rising trend of this leap. Chronic gonorrhea mainly occurs in the elderly and has a higher incidence in Europe and the United States. Some patients have no symptoms in the early stage of the disease, and the disease is only found when they are diagnosed by further examination due to other unrelated diseases or by occasional blood tests that reveal high white blood cell count and abnormal blood tests. Most patients show symptoms such as fatigue, weakness, weight loss, and pallor in the early stages. Patients with chronic gonorrhea may have enlarged and compressed spleen, feeling of heaviness in the upper abdomen, fullness after eating, and decreased appetite. In contrast, lymph node enlargement may be found incidentally in patients with chronic gonorrhea, with enlargement of the lymph nodes in the neck being the first. In patients with chronic gonorrhea, the lymph nodes are usually not enlarged, but on physical examination, the enlarged spleen is obvious, and can often be found at the lower edge of the spleen a few centimeters or at the flat umbilicus during the initial consultation. In addition, there is obvious pressure pain at the lower part of the sternal body. Superficial lymph nodes are often enlarged in patients with chronic gonorrhea, often first in the neck, and on physical examination, axillary and inguinal lymph nodes are also often enlarged. Most of them are moderately enlarged in the early stage, but in the late stage, they can be very large, painless and mobile, and they do not adhere to the surrounding skin tissues. Liver enlargement and spleen enlargement in patients with chronic gonorrhea are less pronounced than in patients with slow granulation, and giant spleen is rare. Anemia may gradually worsen, and there may be nodular or diffuse skin infiltrates. In the late stages of chronic leukemia, both slow-granulomatous and slow-gonorrhea patients may have frequent infections due to decreased immune function, and bleeding often occurs. Chronic leukemia belongs to the category of “deficiency labor”, “blood evidence” and “accumulation” in Chinese medicine. The cause and mechanism of the disease is the seven emotions and fatigue, the organs and organs out of harmony, internal injury to the righteousness, the invasion of evil toxins into the bone marrow, is due to “stasis”, “toxicity”, “phlegm” within the bone marrow, and long-term causes “The deficiency is mainly due to the loss of qi and blood, deficiency of essence and blood, and the evidence of deficiency and reality, with evil toxins as the symptoms and the deficiency as the reality. Clinical treatment of leukemia is mostly based on chemotherapy. However, the side effects of chemotherapy drugs are more damaging to the patient’s body, often after repeated chemotherapy, on top of the original deficiency, aggravated by physical deficiency, resulting in the same deficiency of evil, the disease recurring. The essence of chronic leukemia is the abnormal growth of naive leukocytes in the bone marrow, which is a bone marrow disease, and the bone marrow is a category of the kidney in Chinese medicine, and it is written in the Nei Jing that “the kidney is the master of bone and marrow. Kidney deficiency is the bone marrow is empty, the normal essence and blood can not be born, and easy to cause the evil toxins love the marrow, the disease process for a long time, the poisonous evil has not gone, the righteousness is declining, and become poison into the bone marrow, the righteousness does not overcome the evil, the deficiency coexists with the disease mechanism. The treatment should be based on the use of the slices of Radix Pseudostellariae, Cinnamon, Radix et Rhizoma Ginseng, Radix et Rhizoma Macrocephalae, Radix et Rhizoma Dioscoreae, Cornu Cervi Pantotrichum, Semen Cuscutae, Radix et Rhizoma Bonesetter, etc. to replenish the Yin essence of the kidney and warm the Yang of the kidney, with the use of Lycium barbarum and Fructus Schisandrae, and the use of Radix et Rhizoma Codonopsis, Rhizoma Atractylodis, Radix et Rhizoma Astragali, Rhizoma Yam, Semen Coicis, and Radix et Rhizoma Chrysanthemi to strengthen the spleen and open the stomach, so as to benefit the essence of the latter. At the same time, turtle nail, turtle plate, dragon bone and oyster have the function of softening and dispersing knots, which helps to relieve and dissipate the enlargement of the spleen. During the treatment of this disease, if the white blood cell is low, consider adding cinnamon and sophora; if the red blood cell count is low, add lady’s mantle, dry lotus grass, angelica, aconite, deer gum and turtle gum; if the platelet count is low, add white atractylodes and astragalus; if fever is present, add white flowering snake plant and half branch lotus; if bleeding, add white foxglove root, immortelle and ground elm. This disease in the congenital nature of the kidney deficiency in the tonic, should pay special attention to the kidney Qi deficiency, kidney Yin deficiency, kidney Yang deficiency of the different severity of the disease and differentiate the use of drugs, remember not to supplement the kidney products blindly pile cut, so that not only can not achieve the purpose of replenishing the kidney and fill the essence, improper use of drugs, can also lead to improper kidney tonic caused by more depletion of Yin and blood. If not taken under the guidance of a doctor, it is often easy to cause warm and dry injury to the yin and blood, which is not only ineffective, but also increases adverse reactions and affects the timely and correct treatment of the disease. In the treatment of this disease, supporting the righteousness is the foundation of the treatment of leukemia, and only when the original deficiency is improved can we talk about the righteousness to dispel the evil. It is the foundation of all treatment to protect the deficiency, identify the evidence and supplement, and improve the innate kidney and enrich the innate spleen. In clinical treatment, it has been found that by identifying the symptoms and giving treatment to strengthen the spleen and kidney, nourish Yin and lower fire, and soften the kidney and disperse nodules, it can indeed improve certain abnormal indicators of chronic leukemia in patients with prolonged illness, or chemotherapy, and also improve the therapeutic effect and survival quality of chronic leukemia treated with combined Chinese and Western medicine.