Usually more urine protein means more serious disease in the kidney. However, urine protein 3+ cannot represent the amount of total urine protein, and usually need to do 24-hour urine protein quantification to determine. Therefore, how long it takes for urine protein 3+ to become uremic syndrome is a false proposition. Patients should first do urine protein quantification to determine if they have kidney disease. If there is kidney disease, the pathological type of kidney disease must also be determined, followed by treatment according to the specific cause. Specific treatment effects and individual patient factors, such as the presence of comorbidities, may affect the rate of progression of renal disease, i.e., the time to develop uremia. Therefore, specific problems should be analyzed and no generalization should be made. Therefore, patients with urine protein 3+ should go to the nephrology department of the hospital for examination in time to clarify the cause of the disease, follow the medical advice for targeted drug therapy, follow the medical advice for medication and pay attention to regular review.