For toothache, you can take amoxicillin. Most of the clinical causes of toothache are due to bacterial infection, whether it is due to bacterial infection to the tooth body like caries, apical infection, or bacterial infection to the periodontium like wisdom tooth pericoronitis. The most basic cause of all pain is bacteria, and amoxicillin, as the first line of antibiotics more commonly used in clinical practice, has a certain inhibitory and killing effect on bacteria. However, it is important to point out that the application of amoxicillin is not a cure if the symptoms of toothache occur. Sometimes it can only inhibit the growth of bacteria and temporarily slow down the occurrence of pain, but it cannot treat the root cause of toothache. For example, for tooth decay and apical infection, pulpotomy is required to cure the root cause. For wisdom tooth pericoronitis, the wisdom tooth must be extracted when the pain is mild to cure.