The difference between colitis and colon cancer pain is that colitis pain manifests as paroxysmal pain in the left lower abdomen or lower abdomen, and colon cancer manifests as persistent hidden pain with unknown localization. 1. Colitis: mainly refers to non-specific ulcerative colitis, clinical manifestations are diarrhea, abdominal pain, urgency and heaviness, mucus stools and pus and blood stools, etc. Abdominal pain is usually manifested as paroxysmal pain in the left lower abdomen or the lower abdomen, which can be accompanied by the pattern of abdominal pain – bowel movement – relief after bowel movement, and pain can be relieved by giving anti-inflammatory, antispasmodic and analgesic medicines. 2. Colon cancer: it is a kind of common malignant tumor of digestive tract, which is usually manifested by changes in the number and character of defecation, such as increased frequency of defecation, diarrhea, constipation, blood in stool, etc. Abdominal pain can be manifested as persistent hidden pain of unknown location, or only manifested as abdominal discomfort or abdominal distension, which can be diagnosed through colonoscopy, tumor marker and other examinations. There is a certain difference between the symptoms of colitis and colon cancer, and it is recommended to seek medical treatment in time after discomfort occurs.