The aggravation of gout at night is related to the lack of water in the patient’s body at night, the lowering of body temperature and the decrease in hormone secretion. 1. Insufficient water: the human body will be relatively dehydrated after sleep, at this time, the blood uric acid concentration will be relatively higher and thus make the gout symptoms worse. 2. Low body temperature: As the metabolism of the human body slows down at night, the temperature of the blood in the human body will be reduced accordingly, and at this time the saturation degree of urate will also be reduced due to the lowering of the temperature, and at this time it is easier for urate to be deposited, thus leading to joint pain, swelling and other symptoms. 3. Reduced hormone secretion: adrenal hormone secretion is at its lowest level at night, and some of the hormones in adrenal hormones play an anti-inflammatory role in the body, so it is more likely to flare up at night and the symptoms are relatively serious. The aggravation of gout symptoms at night may also be related to other reasons, and it is recommended that patients go to the rheumatology and immunology department of regular hospitals and other related departments for detailed consultation.